Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome
High androgen induced pyroptosis of ovarian granulosa cells in a mouse model of PCOS, leading to ER stress in oocytes and a decrease of the oocyte maturation rate. Effective alleviation of granulosa cell pyroptosis can inhibit ER stress in oocytes and improve their maturation rate. This study provides new therapeutic targets for improving oocyte maturation in PCOS.
Authors
- Xianguo Xie
- Lei Han (ORCID: https://orcid.org/0000-0001-6487-7520)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-0472-3399)
Institutions
- Ningxia Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13048-025-01841-w
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Program of Ningxia