Maritoclax Overcomes <scp>FBW7</scp> Deficiency‐Driven Irinotecan Resistance in Colorectal Cancer by Targeting <scp>MCL1</scp>
FBW7 deficiency induces irinotecan resistance via MCL1 stabilization, which is therapeutically exploitable by Maritoclax. Our work identifies MCL1 inhibition as a precision strategy for FBW7-deficient CRC and supports clinical translation of Maritoclax-irinotecan combinations.
Authors
- Shuting Liu (ORCID: https://orcid.org/0000-0001-7581-1498)
- Yixin Duan
- Hongfei Jiang (ORCID: https://orcid.org/0000-0001-5869-5253)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-1181-1672)
- Qian Lin (ORCID: https://orcid.org/0000-0002-1513-6993)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/cam4.71419
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Wu Jieping Medical Foundation