E-cigarette exposure and CDP choline modulate withdrawal- induced anxiety and hormonal levels in rats
CDP-choline mitigates the biochemical and behavioral disturbances associated with e-cigarette exposure and withdrawal, highlighting its potential as a therapeutic strategy for nicotine dependence. Future studies incorporating pharmacokinetic profiling, long-term efficacy assessment, and inclusion of female subjects are warranted to further clarify its mechanisms and clinical applicability.
Authors
- Luay Abu-Qatouseh (ORCID: https://orcid.org/0000-0003-1551-2343)
- Abdelrahim M. Alqudah (ORCID: https://orcid.org/0000-0003-3721-8225)
- Muna Barakat (ORCID: https://orcid.org/0000-0002-7966-1172)
- Lujain F. Alzaghari
- Samar H. Thiab (ORCID: https://orcid.org/0000-0002-9625-4915)
- Maram Abdaljaleel (ORCID: https://orcid.org/0000-0002-9257-2596)
- Mohammad A. A. Al-Najjar (ORCID: https://orcid.org/0000-0003-4861-1604)
- Thanaa Al-zuhd
Institutions
- University of Jordan (JO)
- Applied Science Private University (JO)
- Hashemite University (JO)
- American University of Madaba (JO)
- Petra University (JO)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1038/s41598-025-26799-z
- Primary Topic
- Smoking Behavior and Cessation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Applied Science Private University