Melatonin regulates the MST1/Nrf2 pathway to alleviate oxidative stress injury after hypoxic-ischemic brain damage in neonatal rats
Melatonin protects against HIBD by reducing oxidative stress via MST1 inhibition and subsequent Nrf2/HO-1 pathway activation. The MST1-Nrf2 axis is a key mechanism, offering new insights and a potential therapeutic target for neonatal HIE.
Authors
- Xiaoqing Jing (ORCID: https://orcid.org/0009-0006-0181-9271)
- Yuexia Zhang (ORCID: https://orcid.org/0009-0000-3221-3850)
- Xiaoli Wang (ORCID: https://orcid.org/0000-0003-3334-6713)
- Wen‐Liang Gao (ORCID: https://orcid.org/0009-0003-9612-842X)
- Wei Shang (ORCID: https://orcid.org/0009-0007-1874-8972)
- Shuna Yu (ORCID: https://orcid.org/0000-0001-5537-995X)
Institutions
- Weifang Medical University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1080/01616412.2025.2591278
- Citations
- 1
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.81