Cinnamic acid improves insulin sensitivity in prediabetic mice through branched-chain amino acid metabolic reprogramming
CA prevents HFD-induced impairment of insulin sensitivity in prediabetic mice by promoting BCAA catabolism and alleviating adipose inflammation. These findings support its potential as a safe and cost-effective nutrition-based intervention for early prevention of metabolic disorders.
Authors
- Fangfang Lou
- Yongxin Huang (ORCID: https://orcid.org/0000-0003-4050-2876)
- Hongwu Qin (ORCID: https://orcid.org/0000-0001-5330-5711)
- Xin Peng (ORCID: https://orcid.org/0000-0002-6168-9505)
- Jiahui Wang
- Lili Wu (ORCID: https://orcid.org/0000-0001-8601-0637)
- You Wu (ORCID: https://orcid.org/0000-0002-0179-8865)
- Tonghua Liu (ORCID: https://orcid.org/0000-0001-7015-5348)
- Zhiwei Qi (ORCID: https://orcid.org/0009-0004-2022-6872)
Institutions
- Zhejiang Chinese Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Jinhua Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12986-025-01052-6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00