Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly
HOCl and MPO-derived oxidants induce distinct modifications in tropoelastin isoforms, resulting in divergent effects on protein self-assembly. These findings highlight the importance of isoform context in extracellular matrix remodeling under oxidative stress and may have implications for vascular pathologies.
Authors
- Tina Nybo (ORCID: https://orcid.org/0000-0002-6056-4794)
- Adelina Rogowska-Wrzesińska (ORCID: https://orcid.org/0000-0002-9876-0061)
- Michael J. Davies (ORCID: https://orcid.org/0000-0002-5196-6919)
- Karoline Mikkelsen (ORCID: https://orcid.org/0000-0003-0018-5298)
Institutions
- University of Copenhagen (DK)
- University of Southern Denmark (DK)
Publication Details
- Journal
- Redox Report
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1080/13510002.2025.2592409
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Villum Fonden
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Syddansk Universitet
- Novo Nordisk Fonden
- VILLUM Center for Bioanalytical Sciences