Vertebral osteomyelitis and a forgotten dog bite in an immunocompetent patient

A woman in her 60s presented with a three-week history of progressive subacute back pain without neurological deficits. MRI of the lumbar spine demonstrated necrosis at the L3-L4 disc and adjacent vertebral bodies, raising suspicion for malignancy or infection. Two image-guided bone biopsies were nondiagnostic. A peripheral infectious disease workup was similarly unremarkable. Owing to the persistent concern for infection, 16S ribosomal RNA sequencing was performed on biopsy samples, which identified <i>Capnocytophaga canimorsus</i>. Only after receiving this result did the patient recall a minor dog bite sustained six weeks prior to symptom onset. She was managed with an extended course of oral antibiotics with complete clinical recovery. This case illustrates the capacity of <i>C. canimorsus</i> to cause insidious vertebral osteomyelitis in immunocompetent individuals, underscores the diagnostic utility of 16S rRNA sequencing in culture-negative infections, and highlights the critical importance of a detailed exposure history in atypical clinical presentations.

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Publication Details

Journal
Oxford Medical Case Reports
Published
2025-10-19
DOI
https://doi.org/10.1093/omcr/omaf239
Primary Topic
Rabies epidemiology and control
Type
article
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article

Vertebral osteomyelitis and a forgotten dog bite in an immunocompetent patient

B S Giridhar, Nuwan Jasenthu Kankanamage
Oxford Medical Case Reports
Rabies epidemiology and control
article

Vertebral osteomyelitis and a forgotten dog bite in an immunocompetent patient

B S Giridhar, Nuwan Jasenthu Kankanamage
article en

Abstract

A woman in her 60s presented with a three-week history of progressive subacute back pain without neurological deficits. MRI of the lumbar spine demonstrated necrosis at the L3-L4 disc and adjacent vertebral bodies, raising suspicion for malignancy or infection. Two image-guided bone biopsies were nondiagnostic. A peripheral infectious disease workup was similarly unremarkable. Owing to the persistent concern for infection, 16S ribosomal RNA sequencing was performed on biopsy samples, which identified <i>Capnocytophaga canimorsus</i>. Only after receiving this result did the patient recall a minor dog bite sustained six weeks prior to symptom onset. She was managed with an extended course of oral antibiotics with complete clinical recovery. This case illustrates the capacity of <i>C. canimorsus</i> to cause insidious vertebral osteomyelitis in immunocompetent individuals, underscores the diagnostic utility of 16S rRNA sequencing in culture-negative infections, and highlights the critical importance of a detailed exposure history in atypical clinical presentations.

Oxford Medical Case ReportsVol. 2025(11)
Griffith University (AU), Gold Coast Hospital (AU)
Openalex Percentile: Top 61%
Rabies epidemiology and control
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Vertebral osteomyelitis and a forgotten dog bite in an immunocompetent patient — B S Giridhar, Nuwan Jasenthu Kankanamage · Oxford Medical Case Reports (2025) | TGRS Research Map | TGRS