Mycobacteriophage Yasnaya_Polyana and its engineered lytic derivative: specificity of regulatory motifs and lytic potential
These findings suggest that Yasnaya Polyana, and apparently other subcluster K4 phages, harbor distinct regulatory features that may reflect divergent transcriptional control strategies. Moreover, YPΔ47 shows potential as a candidate for phage therapy targeting mycobacterial infections.
Authors
- A. A. Kazyulina
- С. А. Кузнецова (ORCID: https://orcid.org/0000-0001-5946-0026)
- Marina V. Zaychikova (ORCID: https://orcid.org/0000-0002-5016-2089)
- Dmitry V. Bagrov (ORCID: https://orcid.org/0000-0002-6355-7282)
- Maria Kornienko (ORCID: https://orcid.org/0000-0002-1966-8452)
- Egor Shitikov (ORCID: https://orcid.org/0000-0002-4865-6004)
- Margarita O. Shleeva (ORCID: https://orcid.org/0000-0001-7286-9336)
- Ksenia M. Klimina (ORCID: https://orcid.org/0000-0002-5563-644X)
- Anna Vnukova (ORCID: https://orcid.org/0000-0002-1475-1804)
- Mikhail V. Fursov (ORCID: https://orcid.org/0000-0001-9137-9551)
- С. Л. Киселев (ORCID: https://orcid.org/0000-0001-7921-6987)
- Alexandra Lebedeva (ORCID: https://orcid.org/0000-0003-1920-5076)
- Dmitry Bespiatykh (ORCID: https://orcid.org/0000-0003-0867-5988)
- RB Gorodnichev (ORCID: https://orcid.org/0000-0002-1685-1307)
- Maja V. Malakhova
- A Germán
- Aleksandra Strokach
Institutions
- Lomonosov Moscow State University (RU)
- Ministry of Health (MN)
- State Research Center for Applied Microbiology and Biotechnology (RU)
- Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fmicb.2025.1713073
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation
- Lomonosov Moscow State University