Somatostatin regulates the clock sensitivity to evening light

Entrainment of the internal clock to the light-dark cycle is a fundamental feature of biological rhythms. Here, we show that animals genetically deficient for somatostatin (SST) are unable to respond normally to long photoperiodic conditions, showing a significantly delayed phase of activity. The phase delay is also reproduced in the cognate SSTR1 receptor knockout mice and in mice in which SSTR1 is pharmacologically inhibited. We also provide histological evidence that SST inhibits light-induced activation of SSTR1 cells. Furthermore, chronic administration of CH-275, an SSTR1 agonist, normalizes the phase delay of the circadian clock in SST-deficient mice under long photoperiod. Together, these results provide insights into the inhibitory effect of the SST-SSTR1 system in the regulation of light sensitivity of the central clock in the SCN at dusk.

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Publication Details

Journal
Scientific Reports
Published
2025-11-28
DOI
https://doi.org/10.1038/s41598-025-26904-2
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00

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article

Somatostatin regulates the clock sensitivity to evening light

Yoshiaki Yamaguchi, Satoru Masubuchi, Jean‐Michel Fustin, Yasutaka Mizoro et al.
Scientific Reports
Circadian rhythm and melatonin
article

Somatostatin regulates the clock sensitivity to evening light

Yoshiaki Yamaguchi, Satoru Masubuchi, Jean‐Michel Fustin, Yasutaka Mizoro, Miho Sato, Hitoshi Okamura, Kazunori Toida, T. Suzuki, Emi Kiyokage, Keiko Tominaga
article en

Abstract

Entrainment of the internal clock to the light-dark cycle is a fundamental feature of biological rhythms. Here, we show that animals genetically deficient for somatostatin (SST) are unable to respond normally to long photoperiodic conditions, showing a significantly delayed phase of activity. The phase delay is also reproduced in the cognate SSTR1 receptor knockout mice and in mice in which SSTR1 is pharmacologically inhibited. We also provide histological evidence that SST inhibits light-induced activation of SSTR1 cells. Furthermore, chronic administration of CH-275, an SSTR1 agonist, normalizes the phase delay of the circadian clock in SST-deficient mice under long photoperiod. Together, these results provide insights into the inhibitory effect of the SST-SSTR1 system in the regulation of light sensitivity of the central clock in the SCN at dusk.

Scientific ReportsVol. 15(1)
Aichi Medical University (JP), Kawasaki Medical School (JP), Kyoto University (JP), University of Manchester (GB), Kansai University (JP), Kawasaki University of Medical Welfare (JP), Kobe University (JP), The University of Osaka (JP)
Kobayashi International Scholarship Foundation, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology
Openalex Percentile: Top 62%
Circadian rhythm and melatonin
DOIOpen Access PDFOpenAlex
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Somatostatin regulates the clock sensitivity to evening light — Yoshiaki Yamaguchi, Satoru Masubuchi, et al. · Scientific Reports (2025) | TGRS Research Map | TGRS