The interplay between M2-like macrophages and Th17.1 cells promotes the progression of early-stage sarcoidosis
Our study reveals a novel interaction between Th17.1 cells and M2-like macrophages in Type III granulomas potentially mediated through CD47-SIRPα, which may contribute to impaired antigen processing and glucocorticoid resistance in sarcoidosis. Therapies targeting this molecular pathway represent a promising direction for developing new sarcoidosis treatments.
Authors
- Shuanghui Li
- Shengqing Li
- Junzhu Lv
- Daibing Zhou (ORCID: https://orcid.org/0000-0001-7723-1470)
- Mengqi Xu (ORCID: https://orcid.org/0000-0001-8264-7083)
- Wanfeng Xiong (ORCID: https://orcid.org/0000-0003-2817-6780)
- Gulinuer Wumaier
- Ruzetuoheti Yiminniyaze (ORCID: https://orcid.org/0000-0002-9403-9613)
- Yuzhen Zeng
- Jing Wang (ORCID: https://orcid.org/0000-0002-4674-9485)
- Dong Liang (ORCID: https://orcid.org/0000-0002-3166-4235)
- Ning Zhu (ORCID: https://orcid.org/0000-0002-7535-1310)
- Yu Zhao
- An Cui
- Chengwei Li (ORCID: https://orcid.org/0000-0001-6320-1713)
- Xiujuan Zhang (ORCID: https://orcid.org/0009-0007-4268-4171)
- Weiyuan Fang
Institutions
- Huashan Hospital (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12964-025-02566-5
- Citations
- 2
- Primary Topic
- Sarcoidosis and Beryllium Toxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33