[ <scp> <sup>11</sup> C </scp> ]( <i>R</i> )‐ <scp>PK11195</scp> Positron Emission Tomography Imaging of Skull Inflammation in Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder
This is the first in vivo evidence of skull marrow activation in an α-synucleinopathy. Our findings support a role for the skull-meningeal immune axis in iRBD, linking peripheral and central inflammation in prodromal disease. © 2025 International Parkinson and Movement Disorder Society.
Authors
- Rainer Hinz (ORCID: https://orcid.org/0000-0002-7808-9207)
- A. Iranzo (ORCID: https://orcid.org/0000-0002-5618-8271)
- Nicola Pavese (ORCID: https://orcid.org/0000-0002-6801-6194)
- Michael John Firbank (ORCID: https://orcid.org/0000-0002-9536-0185)
- Michael J. Keogh (ORCID: https://orcid.org/0000-0001-7594-7379)
- David J. Brooks (ORCID: https://orcid.org/0000-0003-2602-2518)
- Miriam Højholt Terkelsen (ORCID: https://orcid.org/0000-0003-0971-3747)
- Andreas Myhre Baun (ORCID: https://orcid.org/0009-0007-8099-1367)
- Eduardo Tolosa (ORCID: https://orcid.org/0000-0002-3781-0854)
- Carles Gaig (ORCID: https://orcid.org/0000-0002-7113-8125)
Institutions
- Royal Victoria Infirmary (GB)
- Aarhus University Hospital (DK)
- Centre for Life (GB)
- University of Manchester (GB)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Universitat de Barcelona (ES)
- Newcastle University (GB)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/mds.70133
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Teva Pharmaceutical Industries
- F. Hoffmann-La Roche
- Aarhus Universitet
- Boston Scientific Corporation
- Weston Brain Institute
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- Parkinson's UK
- Newcastle University
- Fonds Wetenschappelijk Onderzoek
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Medical Research Council
- Instituto de Salud Carlos III
- NIHR Newcastle Biomedical Research Centre