Single dose of LSD formulation improves anxiety in Phase 2b trial

Treatment with a single dose of a pharmaceutical formulation of lysergic acid diethylamide (LSD) resulted in a dose‐dependent reduction in anxiety in individuals with generalized anxiety disorder (GAD), a Phase 2b study has found. The two highest of four tested dose strengths of the MM120 formulation demonstrated significant improvement relative to placebo.

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-11-28
DOI
https://doi.org/10.1002/pu.31394
Primary Topic
Psychedelics and Drug Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Single dose of LSD formulation improves anxiety in Phase 2b trial

The Brown University Psychopharmacology Update
Psychedelics and Drug Studies
article

Single dose of LSD formulation improves anxiety in Phase 2b trial

article en

Abstract

Treatment with a single dose of a pharmaceutical formulation of lysergic acid diethylamide (LSD) resulted in a dose‐dependent reduction in anxiety in individuals with generalized anxiety disorder (GAD), a Phase 2b study has found. The two highest of four tested dose strengths of the MM120 formulation demonstrated significant improvement relative to placebo.

The Brown University Psychopharmacology UpdateVol. 37(1)
Openalex Percentile: Top 51%
Psychedelics and Drug Studies
DOIOpen Access PDFOpenAlex
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Single dose of LSD formulation improves anxiety in Phase 2b trial · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS