Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi‐Child Cohort Study
Prenatal exposure to certain ASMs was consistently associated with increased risks of NDDs in offspring. These findings support careful, individualized decision-making regarding prenatal ASM use to minimize neurodevelopmental risks. ANN NEUROL 2026;99:761-776.
Authors
- Michael Pugliese (ORCID: https://orcid.org/0000-0003-2794-1436)
- Steven Hawken (ORCID: https://orcid.org/0000-0002-3341-9022)
- Mark S. Walker (ORCID: https://orcid.org/0000-0002-3276-2689)
- Isabelle Malhamé (ORCID: https://orcid.org/0000-0002-9140-8735)
- Padma Kaul (ORCID: https://orcid.org/0000-0003-2239-3944)
- Lisiane Freitas Leal (ORCID: https://orcid.org/0000-0002-4151-8960)
- Roxana Drăgan (ORCID: https://orcid.org/0000-0002-9744-3590)
- Lucie Morin (ORCID: https://orcid.org/0009-0005-4586-8027)
- Anamaria Savu (ORCID: https://orcid.org/0000-0001-8070-4195)
- Sherif Eltonsy (ORCID: https://orcid.org/0000-0002-0520-5406)
- Raluca Pana (ORCID: https://orcid.org/0000-0003-2590-1983)
- Vanina Tchuente
- Anick Bérard
- Odile Sheehy (ORCID: https://orcid.org/0000-0002-6784-2080)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Manitoba Health (CA)
- Montreal Neurological Institute and Hospital (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- Ottawa Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Ontario Stroke Network (CA)
- Health Outcomes Solutions (United States) (US)
- Ottawa Hospital Research Institute (CA)
- University of Manitoba (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/ana.78084
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research