Comprehensive analysis of gene expression alterations in breast cancer patients via PKCθ-TBK1-mTORC1 signaling pathway
The relative expression of PRKCQ and its associated signaling components suggests their critical role in breast cancer progression. These molecules, especially PRKCQ, may serve as potential biomarkers for early detection and prognosis, as well as targets for therapeutic intervention following further validation.
Authors
- Yasmin Badshah
- Amna Hafeez (ORCID: https://orcid.org/0000-0001-9496-5273)
- Janeen H. Trembley (ORCID: https://orcid.org/0000-0003-3597-2611)
- Sameen Zafar (ORCID: https://orcid.org/0000-0002-1941-7012)
- Suhail Razak (ORCID: https://orcid.org/0000-0003-2167-8630)
- Maria Shabbir (ORCID: https://orcid.org/0000-0002-5685-3059)
- Altaf Khan (ORCID: https://orcid.org/0009-0004-3581-3850)
- Mahnoor Basit
- Tayyaba Afsar (ORCID: https://orcid.org/0000-0003-3181-5731)
Institutions
- University of Minnesota (US)
- King Saud University (SA)
- Minneapolis VA Health Care System (US)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12885-025-15352-w
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00