Fusobacterium nucleatum drives gastric cancer metastasis via Gbp-CypA-NF-κB-mediated CXCL8 crosstalk between tumor cells and mast cells
In summary, this study suggests that Fn contributes to GC progression by promoting tumor cell migration, MCs recruitment and activation. Simultaneously, the enhanced CXCL8-mediated crosstalk between GC cells and MCs plays a vital role in the pro-cancer effect of Fn.
Authors
- Wenkun Li
- Jiayi Su (ORCID: https://orcid.org/0000-0002-3596-5051)
- Wanru Zhang (ORCID: https://orcid.org/0000-0002-8389-6951)
- Tingting Ning (ORCID: https://orcid.org/0000-0002-9986-8023)
- Shuang Hou (ORCID: https://orcid.org/0000-0001-5487-2427)
- Jing Wu (ORCID: https://orcid.org/0009-0004-6080-5908)
- Xinyi Yang (ORCID: https://orcid.org/0009-0000-4943-5492)
Institutions
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12964-025-02561-w
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23