Glycyrrhiza polysaccharide-adjuvanted liposomal vaccine potentiates tumor immunotherapy through lymph node-targeted modulation of the DC-T cell axis
NGUP as a novel vaccine adjuvant for cancer immunotherapy effectively overcomes key limitations of conventional aluminum adjuvants, including weak induction of cell-mediated immunity and significant adverse effects, while exhibiting superior immune-stimulating properties.
Authors
- Hongzhuan Chen (ORCID: https://orcid.org/0000-0002-5367-2949)
- Shengxin Lu
- Keqing Zhang (ORCID: https://orcid.org/0000-0003-2255-8454)
- Yuexuan Wang (ORCID: https://orcid.org/0000-0002-8573-0867)
- Weidong Zhang (ORCID: https://orcid.org/0000-0003-4600-7382)
- Xin Luan (ORCID: https://orcid.org/0000-0003-3674-256X)
- Bei Wang (ORCID: https://orcid.org/0000-0001-5407-7810)
- Xia Liu (ORCID: https://orcid.org/0000-0003-0566-9718)
- Xiao-kun Zhang (ORCID: https://orcid.org/0000-0002-8359-5008)
- Jianxin Hu (ORCID: https://orcid.org/0000-0002-9889-5150)
- Jiayi Lin (ORCID: https://orcid.org/0000-0003-4046-2800)
- Ye Wu (ORCID: https://orcid.org/0009-0007-2317-5152)
- Xiaopan Yao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13046-025-03601-6
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00