Frontiers in mechanobiology and mechanomedicine
Abstract This perspective derives from the presentations and discussions on mechanobiology at the 2025 Cellular and Molecular Bioengineering Conference in San Diego. Mechanobiological processes play critical roles in tissue development, regeneration, and disease progression. Recent advances in engineering, biology, and medicine have enabled the translation of mechanobiology discoveries into clinical practice, giving rise to the emerging field of mechanomedicine. The development and application of engineering technology and tools have provided new insights into how mechanical cues regulate immune cell response, stem cell differentiation, cell migration, and cell metabolism. In this perspective, we highlight exciting discoveries and innovative tools in mechanobiology research, and discuss challenges that must be overcome to truly bridge the gap between mechanobiology and mechanomedicine. Graphical Abstract
Authors
- Haogang Cai (ORCID: https://orcid.org/0000-0003-1700-2531)
- Quinton Smith (ORCID: https://orcid.org/0000-0001-7079-1176)
- Panagiotis Mistriotis (ORCID: https://orcid.org/0000-0002-8069-3278)
- Jacopo Ferruzzi (ORCID: https://orcid.org/0000-0001-7195-589X)
- Longwei Liu (ORCID: https://orcid.org/0000-0003-4229-9066)
- Priscilla Y. Hwang (ORCID: https://orcid.org/0000-0002-7027-3990)
- Peter Yingxiao Wang
- Bo Zhang (ORCID: https://orcid.org/0000-0001-5902-0290)
- Song Li (ORCID: https://orcid.org/0000-0002-8133-3944)
Institutions
- University of Southern California (US)
- University of California, Los Angeles (US)
- The University of Texas at Dallas (US)
- Virginia Commonwealth University (US)
- University of California, Irvine (US)
- NYU Langone Health (US)
- Irvine University (US)
- New York University (US)
- Auburn University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Med-X
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s44258-025-00071-5
- Primary Topic
- Force Microscopy Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00