Decoding epithelial-T cell interactions in colorectal cancer through single-cell and spatial transcriptomics
This study provides an integrative single-cell and spatial atlas of CRC, revealing structured epithelial-T cell communication and spatial architecture within the tumor microenvironment. Our findings offer novel insights into immune-epithelial crosstalk and identify signaling pathways that may serve as therapeutic targets or biomarkers for CRC precision treatment.
Authors
- Rentao Yu (ORCID: https://orcid.org/0000-0003-4952-9274)
- Zhenggang Yue (ORCID: https://orcid.org/0000-0001-6296-8509)
- Xinyu Lü (ORCID: https://orcid.org/0000-0003-4619-0850)
Institutions
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s12672-025-04083-w
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00