Lactate alleviates intestinal barrier injury in weaned piglets via activation of the Wnt/β-catenin pathway and promotion of intestinal epithelial cell proliferation
In summary, lactate ameliorated intestinal barrier damage in DSS-induced colitis by activating the Wnt/β-catenin pathway and restoring the balance between epithelial cell proliferation and apoptosis. This study provides novel mechanistic evidence supporting lactate's therapeutic potential for IBD management.
Authors
- Zhiqing Huang (ORCID: https://orcid.org/0000-0001-5092-9297)
- Ping Zheng (ORCID: https://orcid.org/0000-0002-0055-0358)
- Yuheng Luo (ORCID: https://orcid.org/0000-0002-3124-1179)
- Xiangbing Mao
- Jun He (ORCID: https://orcid.org/0000-0003-3733-0241)
- Aimin Wu (ORCID: https://orcid.org/0000-0001-8322-8833)
- Jie Yu (ORCID: https://orcid.org/0000-0002-8486-1611)
- Daiwen Chen (ORCID: https://orcid.org/0000-0002-8351-7421)
- Yifan Chen (ORCID: https://orcid.org/0000-0001-7922-4776)
- Jiaojiao Chen (ORCID: https://orcid.org/0000-0002-7420-4052)
- Bing Yu (ORCID: https://orcid.org/0000-0002-6954-9259)
- Junqiu Luo (ORCID: https://orcid.org/0000-0002-2484-0966)
- Mingyu Wang (ORCID: https://orcid.org/0009-0002-9177-9509)
Institutions
- Hebei Agricultural University (CN)
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s40104-025-01290-x
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China