SGMS2+ macrophages enhance NR4A3hi NK cell infiltration to improve prognosis and PD-1 treatment efficacy in hepatocellular carcinoma
SGMS2 could polarize macrophages toward the M1 phenotype. SGMS2+ macrophages secrete CXCL2 to recruit CD56dimCD16highNR4A3high NK cells, thereby enhancing tumor apoptosis. High infiltration of SGMS2+ macrophages and CD56dimCD16highNR4A3high NK cells correlates with superior PD-1 therapy responsiveness and extended survival.
Authors
- Zhixue Chen (ORCID: https://orcid.org/0000-0002-1293-7381)
- Fansheng Meng (ORCID: https://orcid.org/0000-0002-4395-8927)
- Fulin Nian
- Hao Zhang (ORCID: https://orcid.org/0000-0002-8201-3272)
- Feng Zhang (ORCID: https://orcid.org/0000-0002-3214-9286)
- Lin Xu (ORCID: https://orcid.org/0000-0002-6889-0279)
- Ye Tao (ORCID: https://orcid.org/0000-0002-2481-7440)
- Biwei Yang (ORCID: https://orcid.org/0000-0003-1854-4877)
- Yueying Chen (ORCID: https://orcid.org/0000-0003-3083-421X)
- Qiuyu Jiang
- Haokang Feng
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12967-025-07040-x
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80