Distinct Effects of Biological Treatments on Eosinophils and Neutrophils in Chronic Rhinosinusitis With Nasal Polyp Patients
Biological treatments effectively reduced eosinophilic inflammation in nasal polyps. However, most biologics could induce an eosinophil-to-neutrophil shift, indicating that solely targeting eosinophils may be insufficient as a treatment approach. Understanding these secondary effects on local immune pathways is critical for optimizing CRSwNP treatment strategies.
Authors
- Natalie De Ruyck (ORCID: https://orcid.org/0000-0001-9985-1347)
- Stijn Vanhee (ORCID: https://orcid.org/0000-0001-5305-1651)
- Manon Blauwblomme (ORCID: https://orcid.org/0000-0001-6263-4883)
- Zhaofeng Xu (ORCID: https://orcid.org/0000-0002-3253-5080)
- Claus Bachert (ORCID: https://orcid.org/0000-0003-4742-1665)
- Sharon Van Nevel (ORCID: https://orcid.org/0000-0002-1417-3303)
- Gabriële Holtappels (ORCID: https://orcid.org/0000-0002-1111-2011)
- Filip Van Nieuwerburgh (ORCID: https://orcid.org/0000-0001-8815-5485)
- Philippe Gevaert (ORCID: https://orcid.org/0000-0002-1629-8468)
- Nan Zhang (ORCID: https://orcid.org/0000-0002-6978-7695)
- Elke Vandewalle (ORCID: https://orcid.org/0000-0003-4307-9743)
Institutions
- Sun Yat-sen University (CN)
- University of Münster (DE)
- Ghent University Hospital (BE)
- Ghent University (BE)
- University Hospital Münster (DE)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- FH Münster University of Applied Sciences (DE)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1002/clt2.70117
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering