Circulating prostaglandin E2 concentrations decrease at birth in premature lambs
Both umbilical cord clamping and ventilation onset independently decrease PGE<sub>2</sub> concentrations immediately after birth, which may enhance breathing activity, although the effect of cord clamping is reduced by ventilation onset.
Authors
- Janneke Dekker (ORCID: https://orcid.org/0000-0002-6710-3587)
- Stuart B. Hooper (ORCID: https://orcid.org/0000-0003-1676-4825)
- Kristel L. A. M. Kuypers (ORCID: https://orcid.org/0000-0003-4407-408X)
- Graeme R. Polglase (ORCID: https://orcid.org/0000-0002-8906-614X)
- Kelly J. Crossley (ORCID: https://orcid.org/0000-0002-1580-1156)
- Alison M. Thiel
- Arjan B. te Pas (ORCID: https://orcid.org/0000-0001-7831-8797)
- Timothy J. R. Panneflek (ORCID: https://orcid.org/0000-0001-8987-3323)
- Thomas van den Akker (ORCID: https://orcid.org/0000-0002-9890-9145)
- E Cannata (ORCID: https://orcid.org/0009-0000-9513-0075)
- Cailin Diedericks (ORCID: https://orcid.org/0009-0001-2921-872X)
- Paige J. Riddington (ORCID: https://orcid.org/0009-0007-8149-6245)
- I. M. Davies (ORCID: https://orcid.org/0009-0008-1505-6791)
- Femmie E. Bloem
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- Hudson Institute of Medical Research (AU)
- Monash University (AU)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fped.2025.1636459
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit Leiden
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council