Elucidating AML ribosome biogenesis reshaping prognostic assessment and immune microenvironment integrated single-cell and bulk RNA analysis
Our study delineates the critical role of ribosome biogenesis in AML progression and establishes an interpretable RBS prognostic signature. This tool effectively assesses immunotherapy responsiveness and reveals novel targeting opportunities, providing valuable insights for clinical decision-making to improve AML outcomes.
Authors
- Xiaohe Chen (ORCID: https://orcid.org/0000-0001-9657-6263)
- Aimei Feng
- Jue Zeng
- Fan Chen (ORCID: https://orcid.org/0000-0002-9602-2102)
- Ming Chen (ORCID: https://orcid.org/0000-0001-5041-9342)
Institutions
- Wenzhou Medical University (CN)
- Ruian People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1644671
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00