Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease
These findings demonstrate the potential of this sulfonamide scaffold while also underscoring metabolic instability and limited systemic exposure as major challenges. Future optimization efforts will focus on structural modifications and formulation strategies to enhance pharmacokinetics and therapeutic efficacy.
Authors
- Ramon B. da Silva (ORCID: https://orcid.org/0000-0003-4215-465X)
- Thaís Cristina Ferreira dos Santos (ORCID: https://orcid.org/0000-0003-2590-9432)
- Valéria Barbosa de Souza (ORCID: https://orcid.org/0000-0002-6462-5718)
- Artur T. Cordeiro (ORCID: https://orcid.org/0000-0002-5676-2456)
- Letícia Marchese (ORCID: https://orcid.org/0000-0002-7688-1188)
- Amanda Gonçalves Eufrásio (ORCID: https://orcid.org/0000-0002-7253-9908)
- Ángel Lobo-Rojas (ORCID: https://orcid.org/0000-0002-1624-8292)
- Marjorie Bruder (ORCID: https://orcid.org/0000-0003-4236-848X)
- André Almeida Schenka (ORCID: https://orcid.org/0000-0002-8162-8996)
- Irene Layane de Sousa (ORCID: https://orcid.org/0000-0002-0894-0545)
- Fabrício Fredo Naciuk (ORCID: https://orcid.org/0000-0001-9176-8821)
- Silvana A. Rocco (ORCID: https://orcid.org/0000-0003-4551-3443)
- Renan Marcel Giampauli
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Brazilian Center for Research in Energy and Materials (BR)
- Brazilian Biosciences National Laboratory (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fphar.2025.1709223
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Ministério da Ciência, Tecnologia e Inovação
- Financiadora de Estudos e Projetos
- Centro Nacional de Pesquisa em Energia e Materiais
- Laboratório Nacional de Biociências