Single‐cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co‐infection
Our study provides a single-cell roadmap of HIV-Mtb co-infection and identifies Th1/Th17 imbalance and MHC-I-biased T-cell signaling reconfiguration as candidate targets for restoring immune homeostasis.
Authors
- Renfang Zhang
- Zihui Zhao (ORCID: https://orcid.org/0000-0002-3421-8732)
- Yinzhong Shen (ORCID: https://orcid.org/0000-0002-7604-5139)
- Wei Huang (ORCID: https://orcid.org/0000-0001-7004-6408)
- Li Liu (ORCID: https://orcid.org/0000-0002-0957-636X)
- Jun Chen (ORCID: https://orcid.org/0000-0001-9506-4012)
- Wei Song (ORCID: https://orcid.org/0009-0000-5612-7228)
- Suyue Huang
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1680538
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00