Periodontitis-associated metabolite isoleucine impairs intestinal barrier function and exacerbates intestinal inflammatory response by NF-κB signaling
Our study unraveled that periodontitis contributed to intestinal barrier function damage and inflammation of intestinal epithelial cells by potentiating NF-κB signaling in the context of colitis and that this was associated with periodontitis-associated metabolite Ile.
Authors
- Xiaohui Rausch‐Fan (ORCID: https://orcid.org/0000-0002-8010-1914)
- Huifang Xie (ORCID: https://orcid.org/0000-0003-3489-3452)
- Marco Aoqi Rausch (ORCID: https://orcid.org/0000-0003-4318-0921)
- Xiaoxue Wang (ORCID: https://orcid.org/0000-0002-7231-9841)
- Jie Ren (ORCID: https://orcid.org/0000-0002-6450-3163)
- Yilin Luo (ORCID: https://orcid.org/0009-0004-8195-3184)
- Xueyang Zhang (ORCID: https://orcid.org/0000-0002-7718-7219)
- Fei Hu (ORCID: https://orcid.org/0000-0001-6150-0955)
Institutions
- Guangdong Province Stomatological Hospital (CN)
- The First People's Hospital of Shunde (CN)
- Stomatology Hospital (CN)
- Southern Medical University (CN)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fcimb.2025.1684362
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Southern Medical University
- Basic and Applied Basic Research Foundation of Guangdong Province