IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone
MI-sensitized individuals exhibit heterogeneous innate immune responses despite uniformly positive patch tests. IL-9, IL-24, and NTRK1 appear to play important roles in the heightened inflammatory response observed in high-responder individuals, while downregulation of IL-18 and IL-37 may contribute to impaired regulatory pathways. These findings highlight previously undescribed heterogeneity in MI-induced ACD and identify potential targets for better understanding disease pathogenesis.
Authors
- Taynah Cohen de Melo (ORCID: https://orcid.org/0000-0002-9910-7515)
- Gabriel Benevides Simões
- Marcella Soares Pincelli (ORCID: https://orcid.org/0000-0001-9754-0705)
- Emanuella Sarmento Alho de Sousa (ORCID: https://orcid.org/0000-0001-8861-635X)
- Frederico Moraes Ferreira (ORCID: https://orcid.org/0000-0002-7403-9165)
- Mírian Nacagami Sotto (ORCID: https://orcid.org/0000-0001-6380-7192)
- Vítor Manuel Silva dos Reis
- Iara Grigoletto Fernandes (ORCID: https://orcid.org/0000-0002-9211-7251)
- Maria Notomi Sato (ORCID: https://orcid.org/0000-0002-7911-1824)
- Yasmim Álefe Leuzzi Ramos (ORCID: https://orcid.org/0009-0005-7185-4569)
Institutions
- Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1685396
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade de São Paulo