Analgesia and sedation increases bronchopulmonary dysplasia risk without significant neurodevelopmental impairment in very preterm infants
In this large Chinese preterm cohort, analgesia/sedation exposure was significantly associated with an increased risk of BPD or death. This association was observed alongside a series of neonatal morbidities such as prolonged IMV and hemodynamic instability, though no significant long-term neurodevelopmental harm was detected at 18 months.
Authors
- Bowen Weng (ORCID: https://orcid.org/0000-0002-7868-9747)
- Chongbing Yan (ORCID: https://orcid.org/0000-0002-1580-5755)
- Yangyang Zhang (ORCID: https://orcid.org/0000-0003-3754-8291)
- Yibo Liu (ORCID: https://orcid.org/0000-0003-2680-9185)
- Cheng Cai (ORCID: https://orcid.org/0000-0001-8994-9674)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fmed.2025.1694251
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University