Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia

Collectively, our results demonstrate that SG therapy imposes reproducible ecological pressures on the lung microbiome and that a two-feature microbial fingerprint can forecast treatment success with single-sample resolution. These findings show that SG therapy actively reshapes the respiratory ecosystem and that lightweight microbiome-aware machine learning can stratify treatment response, offering a tractable path toward precision corticosteroid stewardship.

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Publication Details

Journal
Frontiers in Microbiology
Published
2025-11-28
DOI
https://doi.org/10.3389/fmicb.2025.1706432
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia

Tzong-Yi Lee, Yun‐Long Tang, Yeong-Nan Cheng, Pin‐Kuei Fu et al.
Frontiers in Microbiology
Gut microbiota and health
article

Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia

Tzong-Yi Lee, Yun‐Long Tang, Yeong-Nan Cheng, Pin‐Kuei Fu, Guan-Ting Chen, Yen-Peng Chiu, Wei‐Chih Huang
article en

Abstract

Collectively, our results demonstrate that SG therapy imposes reproducible ecological pressures on the lung microbiome and that a two-feature microbial fingerprint can forecast treatment success with single-sample resolution. These findings show that SG therapy actively reshapes the respiratory ecosystem and that lightweight microbiome-aware machine learning can stratify treatment response, offering a tractable path toward precision corticosteroid stewardship.

Frontiers in MicrobiologyVol. 16
National Yang Ming Chiao Tung University (TW), National Chung Hsing University (TW), Taichung Veterans General Hospital (TW)
Openalex Percentile: Top 66%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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Lung microbiome signatures and explainable predictive modeling of glucocorticoid response in severe community acquired pneumonia — Tzong-Yi Lee, Yun‐Long Tang, et al. · Frontiers in Microbiology (2025) | TGRS Research Map | TGRS