The left DTI-ALPS index: a potential glymphatic mediator of cognitive and motor dysfunction in Parkinson’s disease
Abnormalities in the left DTI-ALPS index and diffusivity reflect underlying glymphatic system (GS) dysfunction and white matter microstructural damage in PD patients. These neuropathological changes are significantly associated with, and collectively contribute to, the progression of motor and cognitive decline. Furthermore, the left DTI-ALPS index shows promise as a novel biomarker for identifying cognitive impairment in PD patients.
Authors
- Xiaoyan Zhou (ORCID: https://orcid.org/0000-0002-4461-1001)
- Xiehua Xue (ORCID: https://orcid.org/0000-0002-9018-1436)
- Zhiwei Lin (ORCID: https://orcid.org/0000-0003-2553-8897)
- Jian Song (ORCID: https://orcid.org/0000-0002-2856-2473)
- Wei Wei (ORCID: https://orcid.org/0000-0003-2754-3948)
- Yanyan Li (ORCID: https://orcid.org/0009-0005-7231-9293)
- Ming Li (ORCID: https://orcid.org/0000-0002-1953-4526)
- Yuqing Zhao (ORCID: https://orcid.org/0009-0004-5205-6791)
- Zhen Zhang (ORCID: https://orcid.org/0000-0003-4307-6577)
- Xueyi Pan (ORCID: https://orcid.org/0000-0002-6504-7577)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Business University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fmed.2025.1674718
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China