Impact of HCV cure on systemic inflammation and bone density, quality, and turnover
HCV cure using DAA was associated with a decrease in systemic inflammation without changes in bone parameters. The significant increase in bone formation markers observed in HIV/HCV co-infected individuals suggests potential bone recovery in this high-risk group, warranting investigation in larger long-term studies.
Authors
- Christina Psomas (ORCID: https://orcid.org/0000-0002-9811-1213)
- Mark Sulkowski (ORCID: https://orcid.org/0000-0002-2145-6352)
- Kendall F. Moseley (ORCID: https://orcid.org/0000-0003-2500-2312)
- Alison G. Abraham (ORCID: https://orcid.org/0000-0002-6863-0565)
- Todd Brown (ORCID: https://orcid.org/0000-0002-3302-8144)
- Jing Sun
- Susan Langan
- Elsa Lellouche-Slama
- Jenny Pena-Dias
- Smita Khati
Institutions
- Johns Hopkins University (US)
- Université Sorbonne Nouvelle (FR)
- Johns Hopkins Medicine (US)
- Sorbonne Université (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre d'Économie de la Sorbonne (FR)
- Université Paris 1 Panthéon-Sorbonne (FR)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1626875
- Citations
- 1
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Johns Hopkins University
- National Institutes of Health
- National Center for Advancing Translational Sciences