Diacetyl-induced bronchiolitis obliterans involves ubiquitin C upregulation and fibrosis-related gene activation in rats
These findings indicate that DA instillation induces early BO-like changes, disrupts ubiquitin regulation, and increases UbC expression, potentially through oxidative stress-related mechanisms. A better understanding of ubiquitin regulation (particularly UbC) may provide novel molecular targets for therapeutic intervention in BO.
Authors
- Hailian Wang (ORCID: https://orcid.org/0000-0002-5536-662X)
- Wei Ge (ORCID: https://orcid.org/0000-0002-4610-7933)
- Jie Xiao (ORCID: https://orcid.org/0000-0002-8964-6347)
- Qing Ye (ORCID: https://orcid.org/0000-0003-4340-9925)
- Wen Jiang
- Yan Geng
Institutions
- Second Hospital of Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fphar.2025.1671557
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Shandong Province