Mapping the landscape of autoimmunity and autoinflammation in inborn errors of immunity: broad distribution with distinct clustering patterns
Recognition of clustering patterns, particularly autoimmune cytopenias, IBD, and endocrine autoimmunity, has direct clinical implications. These manifestations should be regarded as red flags, guiding targeted evaluation and genetic testing. Mapping such associations not only refines our understanding of pathogenesis but also provides a practical framework for earlier diagnosis and tailored management.
Authors
- Abdelghani Yagoubi (ORCID: https://orcid.org/0000-0002-5570-8810)
- L. Taibi
- Faiza Fernini
- Rachida Boukari (ORCID: https://orcid.org/0000-0003-1833-8002)
- Hassen Messaoudi
- Luigi Daniele Notarangelo (ORCID: https://orcid.org/0000-0002-8335-0262)
- Souad Touri
- Leila Smati
- Chafa Bendahmane
- Mohamed Samir Ladj
- Zahir Bouzerar
- Reda Belbouab
- Tahar Bencharif Madani
- A. Saad-Djaballah
- Sergio D. Rosenzweig (ORCID: https://orcid.org/0000-0002-5550-9678)
- Hayet Belhadj
- Ouardia Ibsaine (ORCID: https://orcid.org/0000-0002-8796-662X)
- Dusan Bogunovic (ORCID: https://orcid.org/0000-0002-9277-3232)
- Kamel Djenouhat
- R. Aboura
- Tahar Khelifi Touhami
- Azzeddine Tahiat (ORCID: https://orcid.org/0000-0003-3272-8904)
- Souhila Melzi
- Samira Aggoune (ORCID: https://orcid.org/0000-0002-6013-8066)
- Leila Kedji
- Zouleikha Benhacine
- Rachid Bouhdjila
- Houda Boudiaf
- Saliha Hakem
- Samira Zobiri
- Linda Mokrane
Institutions
- University Frères Mentouri Constantine 1 (DZ)
- University of Algiers Benyoucef Benkhedda (DZ)
- Centre Hospitalo-Universitaire Dr Benbadis Constantine (DZ)
- University of Algiers 3 (DZ)
- Mother Hospital (IN)
- École Normale Supérieure de Constantine (DZ)
- National Institute of Allergy and Infectious Diseases (US)
- Centre de Recherche Nucléaire d’Alger (DZ)
- Centre Hospitalo-Universitaire Bab El Oued (DZ)
- Hôpital Mustapha Pacha (DZ)
- National Institutes of Health Clinical Center (US)
- Université Constantine 2 (DZ)
- Columbia University (US)
- University of Blida (DZ)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1725282
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health