Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis
Age, hypertension, previous cerebrovascular disease, HDL, SIRI, and MoCA score are independent risk factors for moderate to severe WMH occurred. The model integrating MoCA and inflammatory markers accurately predicts moderate to Severe WMH. This study offers a multidimensional assessment framework for WMH risk stratification and early intervention.
Authors
- Jiayu Lv (ORCID: https://orcid.org/0000-0001-8703-4964)
- Shuaiqiang Zhang (ORCID: https://orcid.org/0000-0003-4795-2407)
- Zhiyong Guo (ORCID: https://orcid.org/0000-0003-1288-1573)
- Wenlong Yu (ORCID: https://orcid.org/0000-0002-9003-3943)
- Xia Guo (ORCID: https://orcid.org/0009-0000-9150-3153)
- Lie Wu (ORCID: https://orcid.org/0000-0001-5102-5265)
- Hao Yan (ORCID: https://orcid.org/0000-0003-1468-6165)
- Zhihua Ju (ORCID: https://orcid.org/0000-0003-1703-3215)
- Lu Wang (ORCID: https://orcid.org/0000-0001-7505-7894)
- Yiming Liu (ORCID: https://orcid.org/0000-0003-1810-6084)
- Shitang Ma (ORCID: https://orcid.org/0000-0002-7216-2979)
- Xinhui Li (ORCID: https://orcid.org/0000-0001-5604-9493)
- Hua Li
- Dewang Gao
- Yong Wen
Institutions
- Baogang Group (China) (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fnagi.2025.1667025
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00