Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)
Results obtained in the study demonstrate a dose-dependent effect of BLM on the PF severity, which provides information that will help select BLM dose suitable for obtaining desired degree of PF in animal models.
Authors
- Ekaterina A. Rasskazova
- Ekaterina N. Kazakova
- В. А. Рыков (ORCID: https://orcid.org/0000-0001-5155-3244)
- В. А. Паликов (ORCID: https://orcid.org/0000-0003-2989-4477)
- N. A. Borozdina (ORCID: https://orcid.org/0000-0002-2320-655X)
- В. А. Казаков (ORCID: https://orcid.org/0000-0003-1641-2598)
- E. A. Jain (ORCID: https://orcid.org/0000-0003-0283-8598)
- Yulia A. Palikova (ORCID: https://orcid.org/0000-0001-9547-0686)
- Alina M. Ismailova (ORCID: https://orcid.org/0000-0003-3162-0141)
- А. Н. Мурашев
- Elena A. Tukhovskaya
- Г. А. Слащева (ORCID: https://orcid.org/0000-0002-4422-487X)
- Olga I. Patsap (ORCID: https://orcid.org/0000-0003-4620-3922)
- M. S. Severyukhina
- I. N. Kravchenko (ORCID: https://orcid.org/0000-0002-4662-4332)
- Evgeniy S. Mikhaylov
- Alexander A. Globenko
- Elena A. Kalabina (ORCID: https://orcid.org/0000-0003-1956-2049)
- Andrey Kolosov (ORCID: https://orcid.org/0000-0002-0938-5045)
Institutions
- Peoples' Friendship University of Russia (RU)
- Institute of Bioorganic Chemistry (RU)
- Valent BioSciences (United States) (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fphar.2025.1702991
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00