Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation
BPS can improve renal injury and renal fibrosis in db/db diabetic nephropathy mice, which may be related to the decrease of apoptosis, inhibition of inflammation, reduction of ECM, and regulation of NLRP3 inflammasome. This study provides a scientific basis for the clinical application of BPS in the treatment of renal fibrosis in DN and is expected to promote the drug development and clinical application of BPS.
Authors
- Changwei Tian (ORCID: https://orcid.org/0000-0002-3322-8613)
- Fangyu Zhao (ORCID: https://orcid.org/0000-0002-4191-7355)
- Honglin Yan (ORCID: https://orcid.org/0000-0001-7645-9692)
- Xianbing Chen (ORCID: https://orcid.org/0009-0002-8850-1573)
- Jing‐Long Huang (ORCID: https://orcid.org/0000-0002-3530-7753)
- Jianhong Gao (ORCID: https://orcid.org/0000-0002-8706-9558)
- Tae Hun Song
- Anlin Ma
Institutions
- Minzu University of China (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fphar.2025.1671678
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China