Concomitant medication use and clinical outcome in hepatocellular carcinoma treated with immune-based therapy: a multicenter analysis
This study identified antibiotic use as a negative prognostic factor in HCC treated with ICIs, while glucocorticoid for early TRAEs may indicate improved survival benefits. Concomitant medication may affect the occurrence of TRAEs and warrants careful consideration during ICI treatment.
Authors
- Yu-Nan Zhang
- Yu-Wen Fan
- Yujia Song (ORCID: https://orcid.org/0009-0001-8507-285X)
- Shang-Fu Ning
- Rong Guo (ORCID: https://orcid.org/0000-0003-2799-3463)
- Qing Zhou (ORCID: https://orcid.org/0000-0002-5432-3652)
- Xintong Wu (ORCID: https://orcid.org/0000-0002-7676-3288)
- Jie Xu (ORCID: https://orcid.org/0000-0002-5960-9174)
- Y. Nancy You
- Ming Zhao (ORCID: https://orcid.org/0000-0002-1025-8895)
- Haojie Song (ORCID: https://orcid.org/0000-0003-3201-8750)
- Jiangzheng Zeng (ORCID: https://orcid.org/0000-0002-2382-3961)
- Xin Liu (ORCID: https://orcid.org/0000-0001-8450-6073)
- Lei Li (ORCID: https://orcid.org/0000-0001-9910-5600)
- Jianzhong Zhang (ORCID: https://orcid.org/0000-0001-7056-8206)
- Jun‐Zhe Yi (ORCID: https://orcid.org/0000-0002-0588-2060)
- Ke Ding (ORCID: https://orcid.org/0000-0002-0476-2710)
- Ning Lyu (ORCID: https://orcid.org/0000-0002-8254-1040)
- Gen-Jun Tan
- Minshan Chen (ORCID: https://orcid.org/0000-0002-6116-5015)
- Zhijian Zhu
- Ding Yuan
- Chengmou Huang
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Xuan Wu Hospital of the Capital Medical University (CN)
- Ganzhou People's Hospital (CN)
- Third Affiliated Hospital of Nanchang University (CN)
- Third Hospital of Nanchang (CN)
- Jiangmen Wuyi Traditional Chinese Medicine Hospital (CN)
- Taiyuan Central Hospital (CN)
- Boai Hospital of Zhongshan (CN)
- Yantaishan Hospital (CN)
- Seventh People's Hospital of Shanghai (CN)
- Sun Yat-sen University Cancer Center (CN)
- Jiangmen Central Hospital (CN)
- Chenzhou First People's Hospital (CN)
- Guangzhou Chest Hospital (CN)
- Cixian People's Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1680015
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province