Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

These findings implicate <i>OPRK1</i> genetic variation in several opioid-abstinence phenotypes. These results, if replicated, could improve understanding of the course and treatment of OUD.

Authors

Margit Burmeister (ORCID: https://orcid.org/0000-0002-1914-2434)
Mark K. Greenwald (ORCID: https://orcid.org/0000-0002-9541-7321)
Catherine Demery‐Poulos (ORCID: https://orcid.org/0009-0002-2349-3613)
Tabitha E.H. Moses (ORCID: https://orcid.org/0000-0002-6978-5032)

Institutions

Wayne State University (US)
University of Michigan (US)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2025-11-28
DOI: https://doi.org/10.3389/fphar.2025.1714546
Primary Topic: Pain Management and Opioid Use
Type: article
Field-Weighted Citation Impact: 0.00

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article

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

Margit Burmeister, Mark K. Greenwald, Catherine Demery‐Poulos, Tabitha E.H. Moses

Nov 28, 2025

Frontiers in Pharmacology

Pain Management and Opioid Use

article

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

Margit Burmeister, Mark K. Greenwald, Catherine Demery‐Poulos, Tabitha E.H. Moses

November 28, 2025article en

Abstract

These findings implicate <i>OPRK1</i> genetic variation in several opioid-abstinence phenotypes. These results, if replicated, could improve understanding of the course and treatment of OUD.

Frontiers in PharmacologyVol. 16

Wayne State University (US), University of Michigan (US)

Openalex Percentile: Top 45%

Pain Management and Opioid Use

DOI Open Access PDF OpenAlex

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Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users — Margit Burmeister, Mark K. Greenwald, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS