Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis
These findings suggest impairments in cytotoxic immune cells along with a widespread immune exhaustion and an aberrant activation in adult HLH. The results also indicate potential differentiation defects in CD8<sup>+</sup> T cells and NK cells. Treatment with a PD-1 inhibitor may contribute to partial functional recovery and support viral clearance in EBV-HLH, which warrant further investigation.
Authors
- Xinchuan Chen (ORCID: https://orcid.org/0000-0001-9292-9623)
- Xushu Zhong (ORCID: https://orcid.org/0000-0001-5194-1394)
- Yao Qin
- Huanling Zhu (ORCID: https://orcid.org/0000-0002-5226-3828)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Yun Tang (ORCID: https://orcid.org/0000-0001-8244-5668)
- Jianying Zhou
- Yang Dai
- Pengpeng Liu (ORCID: https://orcid.org/0000-0003-3465-1402)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1678233
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University