Evaluation of Aminoglycoside Dosing Regimens Adjusted for Renal Function and In Vitro Susceptibility Test Interpretive Criteria for Enterobacterales and <i>Pseudomonas aeruginosa</i> : Brief Summary
The results of pharmacometric analyses for aminoglycosides were used to support recommendations for dosing regimens adjusted for renal function and a reassessment of the United States Committee on Antimicrobial Susceptibility Testing susceptibility test interpretive criteria for Enterobacterales and <i>Pseudomonas aeruginosa</i>. Susceptible and susceptible-based on therapeutic drug monitoring breakpoints are recommended for extended-interval amikacin, gentamicin, and tobramycin dosing regimens, thus representing adaptable treatable approaches.
Authors
- John S. Bradley (ORCID: https://orcid.org/0000-0002-3835-5064)
- David R. Andes (ORCID: https://orcid.org/0000-0002-7927-9950)
- Nikolas J. Onufrak (ORCID: https://orcid.org/0000-0002-2649-709X)
- William A. Craig
- George L. Drusano (ORCID: https://orcid.org/0000-0001-9162-7332)
- Sujata M. Bhavnani (ORCID: https://orcid.org/0000-0003-4891-6467)
- Paul G. Ambrose (ORCID: https://orcid.org/0000-0002-2230-1125)
- Jason M. Pogue (ORCID: https://orcid.org/0000-0003-4780-6215)
- Hélio S. Sader (ORCID: https://orcid.org/0000-0001-7022-6644)
- Ronald N. Jones
- Jeffrey Hammel
Institutions
- University of Wisconsin–Madison (US)
- University of San Diego (US)
- University of Michigan (US)
- University of Florida (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Michigan Medicine (US)
- Institute for Clinical Pharmacodynamics (United States) (US)
- Institute for Learning Innovation (US)
- JMI Laboratories (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-11-22
- DOI
- https://doi.org/10.1093/ofid/ofaf427
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00