The DO-KB knowledgebase 2026 update: expanding programmatic and language access
The Human Disease Ontology Knowledgebase (DO-KB; https://disease-ontology.org/), a Global Core Biodata Resource, serves as a reference framework for multiscale biomedical data integration and analysis, within a unifying etiology-based disease classification. In this 2026 update of the Human Disease Ontology (DO) and DO-KB resource, we present significant advances in programmatic data retrieval and disease representation since our previous NARdb publication. Here we report on the development of a DO Nosology education program, the Spanish translation of the DO website and ontology content, and expansion of disease knowledge representation.
Authors
- Saadia Zahid (ORCID: https://orcid.org/0000-0003-1667-554X)
- Rachel Castillo
- Cynthia F. Bearer (ORCID: https://orcid.org/0000-0003-4809-2250)
- Ginette Dobbins
- Emily Bliss (ORCID: https://orcid.org/0000-0002-2754-4556)
- Victor Felix (ORCID: https://orcid.org/0000-0001-7825-6418)
- A. Widjaja (ORCID: https://orcid.org/0009-0000-2850-775X)
- Katharine Bisordi (ORCID: https://orcid.org/0000-0001-7380-4817)
- Sarah Louise Edwards (ORCID: https://orcid.org/0000-0001-8966-5065)
- Michael Schor (ORCID: https://orcid.org/0000-0002-4493-7992)
- Rima Koka (ORCID: https://orcid.org/0000-0002-0457-8489)
- Lance Nickel (ORCID: https://orcid.org/0000-0002-5836-3571)
- Matthew Fairchild
- Shannan Dixon
- Dustin Olley (ORCID: https://orcid.org/0000-0001-8685-0839)
- J. Allen Baron (ORCID: https://orcid.org/0000-0002-0593-3569)
- Peter Gaskin
- Catherine Johnson
- Susan M. Bello (ORCID: https://orcid.org/0000-0003-4606-0597)
- Melissa D. Clarkson (ORCID: https://orcid.org/0000-0001-9979-176X)
- Regina A. Macatangay (ORCID: https://orcid.org/0000-0002-3868-3287)
- Lynn M. Schriml (ORCID: https://orcid.org/0000-0001-8910-9851)
- Yoshihiro Usui
- Carol L. Greene (ORCID: https://orcid.org/0000-0001-8219-8767)
- Richard Lichenstein
- Erin Lynch
- Todd Detwiler
- Kaitlin Ballenger
- Harrison Heitzig
- Patrick Semesky
- Nischal Ada
- Lauren Colliver
- Jennifer Garth
Institutions
- University of Maryland, Baltimore (US)
- University of Kentucky (US)
- University of South Carolina (US)
- Jackson Laboratory (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Nucleic Acids Research
- Published
- 2025-10-21
- DOI
- https://doi.org/10.1093/nar/gkaf1213
- Primary Topic
- Biomedical Text Mining and Ontologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00