Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two‐sample Mendelian randomization
Our findings provide genetic evidence supporting a potential causal association between lymphocyte counts and diabetic retinopathy risk, while the association for eosinophil counts was attenuated after correction for outliers. These results highlight the importance of further investigating the physiological role of lymphocytes in diabetic retinopathy to inform effective prevention and treatment strategies.
Authors
- Jiaxin Wu (ORCID: https://orcid.org/0000-0003-1139-2743)
- Lixia Guo (ORCID: https://orcid.org/0000-0002-2966-4527)
- Xiaoqiang Zhang (ORCID: https://orcid.org/0000-0001-5340-7697)
- Yan Wang (ORCID: https://orcid.org/0000-0002-9288-3079)
- Zhiqiang Wang (ORCID: https://orcid.org/0000-0002-5839-743X)
- Shanshan Shang (ORCID: https://orcid.org/0000-0001-7515-1610)
- Yunxian Gao (ORCID: https://orcid.org/0000-0003-0927-780X)
- Lijing Wu (ORCID: https://orcid.org/0000-0002-0736-9826)
Institutions
- Beijing University of Chinese Medicine (CN)
- Binzhou Medical College Hospital (CN)
- Binzhou People's Hospital (CN)
- Xinjiang Uygur Autonomous Region Uygur Medicine Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1111/jdi.70196
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00