Causal associations between circulating metabolites and risk of neuroblastoma: a bidirectional Mendelian randomization study
This research identifies bidirectional causal relationships between circulating metabolites and NB. Increased levels of blood butyrylcarnitine are associated with a reduced risk of NB, whereas lower levels of guanosine and higher levels of 3-methyl-2-oxobutyrate are indicative of NB patients. Further investigation is required for the mechanisms.
Authors
- Qiuhui Pan (ORCID: https://orcid.org/0000-0001-7386-2590)
- Qizhi Diao (ORCID: https://orcid.org/0000-0003-1121-4656)
- Zhe Zhao (ORCID: https://orcid.org/0000-0003-2124-0452)
- Chang-Lin Chen (ORCID: https://orcid.org/0000-0002-4199-1715)
- Han Wu
- Chaoyan Yue (ORCID: https://orcid.org/0000-0002-0597-8388)
Institutions
- Xuzhou Medical College (CN)
- Huaian First People’s Hospital (CN)
- Second People’s Hospital of Huai’an (CN)
- Xuzhou No.1 People's Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Sanya City Women and Children Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s12672-025-04172-w
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00