Revascularization of human ovarian cortical grafts is not equally efficient from both sides of the cortex tissue
Human ovarian grafts demonstrated superior revascularization and significantly reduced apoptosis at the medullary interface compared to the cortical surface. The restoration of hormone levels confirmed functional graft survival, validating the experimental model. These findings underscore the significance of surgical orientation in facilitating graft revascularization and mitigating cellular stress during early ovarian tissue transplantation.
Authors
- Yanglu Li
- Anming Liu (ORCID: https://orcid.org/0000-0002-7419-3752)
- Lingling Jiang (ORCID: https://orcid.org/0000-0003-4694-6419)
- Xiangyan Ruan (ORCID: https://orcid.org/0000-0001-7777-247X)
- Jing Jin (ORCID: https://orcid.org/0000-0002-3250-9173)
- Yanqiu Li (ORCID: https://orcid.org/0009-0001-1119-0685)
- Juan Du (ORCID: https://orcid.org/0000-0001-7751-6994)
- Muqing Gu
- Fengyu Jin
- Mingzhen Zhang (ORCID: https://orcid.org/0000-0002-4686-6526)
- Jiaojiao Cheng
- Alfred Otto Mueck
- Zecheng Wang
Institutions
- Women's Hospital (US)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fendo.2025.1679248
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- Beijing Obstetrics and Gynecology Hospital, Capital Medical University