Impaired AMP-Dependent Protein Kinase-Mediated Neutrophil Extracellular Trap Clearance by Aged Macrophages in Sepsis-Induced Liver Injury
Aging impairs AMPK-mediated macrophage clearance of NETs in the liver, exacerbating liver inflammatory injury. Focusing on NETs could offer a therapeutic strategy to mitigate liver damage and reduce mortality in elderly sepsis patients.
Authors
- Bo Zhou (ORCID: https://orcid.org/0000-0001-5656-2123)
- Weizhe Zhong
- Zhuqing Rao (ORCID: https://orcid.org/0000-0002-2943-780X)
- Zhu Guan
- Fei Li (ORCID: https://orcid.org/0000-0002-4695-944X)
- Haoming Zhou (ORCID: https://orcid.org/0000-0003-2778-221X)
- Yan Bai
- Xingyue Ji
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1213/ane.0000000000007831
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00