Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB

CLGN is a pivotal ERS effector mediating HCC apoptosis resistance through NF-κB. Sh-CLGN combined with Pae restores apoptotic sensitivity via dual CLGN/NF-κB inhibition, providing a potent strategy against ERS-adapted HCC.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-11-28
DOI
https://doi.org/10.3389/fonc.2025.1709962
Primary Topic
Endoplasmic Reticulum Stress and Disease
Type
article
Field-Weighted Citation Impact
0.00

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article

Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB

Sitong Yan, Guoping Sun, Yue Zhu, Xiaoqiang Du et al.
Frontiers in Oncology
Endoplasmic Reticulum Stress and Disease
article

Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB

Sitong Yan, Guoping Sun, Yue Zhu, Xiaoqiang Du, Jiatao Liu, Xiangyu Zu, Anqi Wang, Lingling Zhang, Xiang Chen, Yu-Han Huang, Lulu Fan, Weijia Jiang
article en

Abstract

CLGN is a pivotal ERS effector mediating HCC apoptosis resistance through NF-κB. Sh-CLGN combined with Pae restores apoptotic sensitivity via dual CLGN/NF-κB inhibition, providing a potent strategy against ERS-adapted HCC.

Frontiers in OncologyVol. 15
Nanchang University (CN), Anhui Medical University (CN), Anhui University of Traditional Chinese Medicine (CN), First Affiliated Hospital of Anhui Medical University (CN), First Affiliated Hospital of Bengbu Medical College (CN), First Affiliated Hospital of Nanchang University (CN)
National Natural Science Foundation of China, Anhui Medical University
Openalex Percentile: Top 61%
Endoplasmic Reticulum Stress and Disease
DOIOpen Access PDFOpenAlex
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Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB — Sitong Yan, Guoping Sun, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS