A‐to‐I RNA Edited miR‐605‐3p Has a Heightened Anti‐Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6

The A-to-I RNA edited miR-605-3p demonstrates a more potent anti-tumor effect in CRC by modulating CD8+ T cell immune infiltration mediated by CDK6. This study unveils edited miR-605-3p as a potential prognostic biomarker and highlights the ADAR2-miR-605-3p axis as a novel therapeutic target for CRC.

Authors

Shuai Wang (ORCID: https://orcid.org/0000-0001-5670-1381)
Danyang Li (ORCID: https://orcid.org/0000-0001-7470-6645)
Xiujun Cai (ORCID: https://orcid.org/0000-0003-2514-1486)
C Y Guo (ORCID: https://orcid.org/0009-0006-3225-9027)
Kuang Gou

Institutions

Xian Yang Central Hospital (CN)

Publication Details

Journal: The Journal of Gene Medicine
Published: 2025-11-26
DOI: https://doi.org/10.1002/jgm.70060
Primary Topic: RNA regulation and disease
Type: article
Field-Weighted Citation Impact: 0.00

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article

A‐to‐I RNA Edited miR‐605‐3p Has a Heightened Anti‐Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6

Shuai Wang, Danyang Li, Xiujun Cai, C Y Guo et al.

Nov 26, 2025

The Journal of Gene Medicine

RNA regulation and disease

article

A‐to‐I RNA Edited miR‐605‐3p Has a Heightened Anti‐Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6

Shuai Wang, Danyang Li, Xiujun Cai, C Y Guo, Kuang Gou

November 26, 2025article en

Abstract

The A-to-I RNA edited miR-605-3p demonstrates a more potent anti-tumor effect in CRC by modulating CD8+ T cell immune infiltration mediated by CDK6. This study unveils edited miR-605-3p as a potential prognostic biomarker and highlights the ADAR2-miR-605-3p axis as a novel therapeutic target for CRC.

The Journal of Gene MedicineVol. 27(12)

Xian Yang Central Hospital (CN)

Openalex Percentile: Top 66%

RNA regulation and disease

DOI Source OpenAlex

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A‐to‐I RNA Edited miR‐605‐3p Has a Heightened Anti‐Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6 — Shuai Wang, Danyang Li, et al. · The Journal of Gene Medicine (2025) | TGRS Research Map | TGRS