Adjunctive effects of intermittent fasting and exercise with glibenclamide on diabetic nephropathy in rats: a potential role of the polyol pathway
The combination of glibenclamide, exercise, and IF provides synergistic protection against diabetes-induced nephropathy, primarily through modulation of the polyol pathway, antioxidant enhancement, and suppression of inflammation and fibrosis.
Authors
- Hend M Hassan (ORCID: https://orcid.org/0000-0001-9390-8226)
- Emad Ali Albadawi (ORCID: https://orcid.org/0000-0002-4850-9178)
- Neven A. Ebrahim (ORCID: https://orcid.org/0000-0002-7358-6618)
- Shereen M. Samir
- Rasha Elmowafy
- Wejdan H. Owaydhah
- Muayad Albadrani (ORCID: https://orcid.org/0000-0002-7486-1677)
- Mona Elhadidy (ORCID: https://orcid.org/0000-0002-9385-6830)
Institutions
- Damietta University (EG)
- Mansoura University (EG)
- Taibah University (SA)
- Al Baha University (SA)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fphys.2025.1683271
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00