Phenolic profile of different solvent extracts of Reseda alba L. and evaluation of anti-quorum sensing, antioxidant, and enzyme inhibition activities
The results demonstrate that <i>R. alba</i> extracts (RAEs) possess significant inhibitory effects on enzymes implicated in neurodegenerative disorders, such as Alzheimer's disease, particularly through butyrylcholinesterase inhibition. Additionally, the extracts show promising anti-quorum sensing and anti-swarming activities, which could reduce microbial virulence and biofilm formation, suggesting potential as alternative antimicrobial agents. The moderate antioxidant activity further supports its therapeutic potential. Overall, <i>R. alba</i> could be developed as a natural source for managing enzyme-related diseases and controlling bacterial infections by targeting microbial communication mechanisms.
Authors
- Selçuk Küçükaydın (ORCID: https://orcid.org/0000-0001-8538-6528)
- Louiza Boudiba (ORCID: https://orcid.org/0000-0002-2705-8515)
- Alfred Ngenge Tamfu (ORCID: https://orcid.org/0000-0001-6683-3337)
- Ayomide Victor Atoki (ORCID: https://orcid.org/0000-0003-1914-973X)
- Mohammed Nacer (ORCID: https://orcid.org/0000-0003-2322-5846)
- Karima Hanini (ORCID: https://orcid.org/0000-0002-4624-3396)
- Soraya Hioun (ORCID: https://orcid.org/0000-0002-2071-8701)
- Özgür Ceylan (ORCID: https://orcid.org/0000-0002-1865-1093)
- Ashok K. Kalla
- Mohammed Messaoudi (ORCID: https://orcid.org/0000-0002-3536-6358)
- Khattabi Latifa
Institutions
- Kampala International University (UG)
- Biotechnology Research Center (IR)
- Université Larbi Tébessi (DZ)
- École Normale Supérieure de Kouba (DZ)
- University of Ngaoundéré (CM)
- Muğla University (TR)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fnut.2025.1699534
- Citations
- 1
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.81