Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon
GC-C activation leads to CFTR-mediated ASR in all segments of the intestine. In the mid and distal colon ASR is strongly reduced by the low cGKII and high PDE9 expression, with the CFTR channel being activated via cAMP-mediated phosphorylation.
Authors
- Ursula Elisabeth Seidler (ORCID: https://orcid.org/0000-0002-9600-2769)
- Azam Salari (ORCID: https://orcid.org/0009-0001-4366-8436)
- Johannes Reiner
- Franz Hofmann (ORCID: https://orcid.org/0000-0001-8571-1001)
- Renjie Xiu
Institutions
- Medizinische Hochschule Hannover (DE)
- München Klinik (DE)
- University of Rostock (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1111/bph.70245
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00